Recombinant Human AIFM1 Protein, His-tagged

• Cat.No.: AIFM1-313H
• Product Overview: Recombinant Human AIFM1(Glu121-Asp613), transcript variant 4, fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.
• Molecular Mass: 56.2 kDa
• Protein length: Glu121-Asp613
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
• Concentration: Resuspend the protein to the desired concentration in proper buffer.

Gene Information

• Gene Name: AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 [ Homo sapiens ]
• Official Symbol: AIFM1
• Synonyms: AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; PDCD8, programmed cell death 8 (apoptosis inducing factor); apoptosis-inducing factor 1, mitochondrial; AIF; striatal apoptosis-inducing factor; programmed cell death 8 (apoptosis-inducing factor); PDCD8; COXPD6; MGC111425
• Gene ID: 9131
• mRNA Refseq: NM_001130846
• Protein Refseq: NP_001124318
• MIM: 300169
• UniProt ID: O95831