AIFM1
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Official Full Name
apoptosis-inducing factor, mitochondrion-associated, 1 -
Overview
Apoptosis-inducing factor (Aif) is a ubiquitously expressed ~57 kDa mitochondrial flavoprotein (67-70 kDa primary transcript) that is capable of inducing chromatin condensation following an apoptotic stimulus. Synthesized in the cytoplasm, Aif is translocated to the intermembrane space of the mitochondria where it is normally found in non-apoptotic cells. Following an apoptotic signal, Aif is released to the cytoplasm from where it is translocated to the nucleus. Once in the nucleus, Aif is capable of inducing nuclear chromatin condensation and large scale DNA fragmentation. Redistribution of the Aif protein can be blocked by bcl-2. -
Synonyms
AIFM1;apoptosis-inducing factor, mitochondrion-associated, 1;PDCD8, programmed cell death 8 (apoptosis inducing factor);apoptosis-inducing factor 1, mitochondrial;AIF;striatal apoptosis-inducing factor;programmed cell death 8 (apoptosis-inducing factor);PDCD8;COXPD6;MGC111425
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Rhesus macaque
- Rat
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
AIFM1 involved in several pathways and played different roles in them. We selected most pathways AIFM1 participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIFM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | BIRC5A,IRAK3,STK26,CYCS,CYCSB,PIK3R2,IRF4,LMNB1,CAPN2A,BCL2L11 |
Protein Function
AIFM1 has several biochemical functions, for example, DNA binding,FAD binding,NAD(P)H oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AIFM1 itself. We selected most functions AIFM1 had, and list some proteins which have the same functions with AIFM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FAD binding | DAO,MTRR,ACOX1,CRY2,CYB5R3,DAO.1,MICAL2B,COQ6,DAO1,MICAL1 |
| DNA binding | HNRPK,HOXB1,ESRRGA,PEG10,CERS4,DMBX1,IRX7,ZNF2,STAT5B,ZBTB26 |
| electron carrier activity | GSR,CYP1A2,GLRX5,CYP19A1,UQCR11,UGDH,GCDHA,COX7A3,NDUFS3,ACADL |
| protein dimerization activity | HEY1,SOHLH1,MITF,RIMKLB,TFAP2C,NCOA1,GGN,HER12,PPP3CB,ATOH7 |
| NAD(P)H oxidase activity | KMO,NOX4,CYB5R4,DUOX2,DERL3 |
| oxidoreductase activity, acting on NAD(P)H | NDUFS8B,DERL3,ECSIT,NDUFS8A,DECR1,WDR93,MIOX |
| protein binding | CNTF,ZFP36L1,CTNNA2,DBC1,PKIA,CDKN1B,SH2B2,INCENP,ITGA4,AUP1 |
Interacting Protein
AIFM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIFM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIFM1.
EIF3G;KANK2;HSPA1A;ILK;TSC22D4;PPIA
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