Recombinant Human AGRN, His-tagged
Cat.No. : | AGRN-26658TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 1601-2045 of Human Agrin with a N terminal His tag; 52kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 1601-2045 a.a. |
Description : | This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. |
Conjugation : | HIS |
Form : | Lyophilised:Reconstitution with 127 μl aqua dest. |
Storage buffer : | Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | APCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADF NGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLL YNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSR EPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTV LNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLG GRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASC VPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSG KATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVN TNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLD TDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHP LHLLEDAVTKPELRPCPTP |
Gene Name | AGRN agrin [ Homo sapiens ] |
Official Symbol | AGRN |
Synonyms | AGRN; agrin; AGRIN; agrin proteoglycan; |
Gene ID | 375790 |
mRNA Refseq | NM_198576 |
Protein Refseq | NP_940978 |
MIM | 103320 |
Uniprot ID | O00468 |
Chromosome Location | 1p36.33 |
Pathway | Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; |
Function | acetylcholine receptor regulator activity; laminin binding; protein binding; structural constituent of cytoskeleton; |
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Not For Human Consumption!
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