AGRN
-
Official Full Name
agrin -
Overview
may play a role in synapse development and regeneration -
Synonyms
AGRN;agrin;agrin proteoglycan
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- CHO
- E.coli
- Sf9 Cells
- Mammalian Cells
- Sf21 Cells
- HEK293
- His
- T7
- Non
- Avi
- Fc
Involved Pathway
AGRN involved in several pathways and played different roles in them. We selected most pathways AGRN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,Axon guidance,Chondroitin sulfate/dermatan sulfate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | GPC5,GPC6 |
| Defective EXT2 causes exostoses 2 | GPC5,GPC6 |
| Defective B3GAT3 causes JDSSDHD | DCN,CSPG5,BCAN,NCAN,VCAN,GPC6,BGN,CSPG4,GPC5 |
| Chondroitin sulfate/dermatan sulfate metabolism | GPC6,BCAN,DCN,CHST9,GPC5A,BGN,GPC1B,CSPG5B,GPC5,VCAN |
| Axon guidance | EFNA3,CNKSR1,COL4A4,DUSP1,WDR83,KALRNB,RND1,AP2A2,EFNA2,SPTBN2 |
| Defective B4GALT7 causes EDS, progeroid type | GPC5,NCAN,CSPG4,DCN,BGN,VCAN,CSPG5,BCAN,GPC6 |
| A tetrasaccharide linker sequence is required for GAG synthesis | VCANB,DCN,VCAN,CSPG5B,GPC6,BCAN,CSPG4,CSPG5,B3GAT2,B4GALT7 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | DCN,GPC5,VCAN,BCAN,GPC6,NCAN,CSPG4,CSPG5,BGN |
Protein Function
AGRN has several biochemical functions, for example, acetylcholine receptor regulator activity,calcium ion binding,chondroitin sulfate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGRN itself. We selected most functions AGRN had, and list some proteins which have the same functions with AGRN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | TUBD1,TUBA1B,TUBB1,CCDC6,EPB41L3,BFSP1,TUBB2B,COX4I2,KRT17,TUBA3C |
| heparan sulfate proteoglycan binding | GPC1A,GPC1B,GPC6,HRG,GPC6A,SLIT2,COMP,SEMA5A,GPC5A,Itgam&Itgb2 |
| chondroitin sulfate binding | EMR2,DPYSL3 |
| dystroglycan binding | DAG1,VCL,AGR2,AGR3,MAP2,GYLTL1B,CLASP1,DMD |
| laminin binding | LGALS1,ITGB1,LRRC15,THBS1,ITGA9,LYPD3,LGALS3,LGALS2A,ADAM9,ITGA3 |
| protein binding | ELP3,BOLA1,SUV420H2,RFPL4,GDPD5,RPS20,DLGAP4,SERTAD3,CD151,BOLL |
| calcium ion binding | CABP2A,CALRL2,EFHC2,THBS4B,MYL1,ANXA10,ASPH,CABP1B,CABP5A,EFCAB4B |
| sialic acid binding | FCN1,Siglece,ADIPOQ,SELP,ST8SIA2,ST8SIA3,SELE,L1CAM |
| acetylcholine receptor regulator activity | FNTA |
Interacting Protein
AGRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGRN here. Most of them are supplied by our site. Hope this information will be useful for your research of AGRN.
ATXN7;PDIA3;Npnt;CACNA1A;ATN1;GFI1B;midostaurin;PYHIN1;APP
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