Recombinant Human ADK, His-tagged

• Cat.No.: ADK-26098TH
• Product Overview: Recombinant fragment, corresponding to amino acids 22-362 of Human ADK with N terminal His tag, 362 amino acids with tag, MWt 40.5kDa.

Specification

• Description: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Widely expressed. Highest level in placenta, liver, muscle and kidney.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD FH
• Sequence Similarities: Belongs to the carbohydrate kinase pfkB family.
• Protein length: 22-362 a.a.

Gene Information

• Gene Name: ADK adenosine kinase [ Homo sapiens ]
• Official Symbol: ADK
• Synonyms: ADK; adenosine kinase; adenosine 5 phosphotransferase; AK
• Gene ID: 132
• mRNA Refseq: NM_001123
• Protein Refseq: NP_001114
• MIM: 102750
• Uniprot ID: P55263
• Chromosome Location: 10q22.2
• Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, organism-specific biosystem
• Function: ATP binding; adenosine kinase activity; kinase activity; metal ion binding; nucleotide binding