ADK
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Official Full Name
adenosine kinase -
Overview
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADK;adenosine kinase;adenosine 5 phosphotransferase;AK;5033405D03Rik;AI255373;AI987814;MGC6593;2310026J05Rik;ADK_HUMAN;OTTHUMP00000019864;OTTHUMP00000019865;adenosine 5-phosphotransferase
Recombinant Proteins
- Human
- Mouse
- Bacillus subtilis
- S.flexneri
- Chicken
- Rhesus macaque
- Staphylococcus
- Rat
- Streptomyces coelicolor A3(2)
- E.coli
- Mycobacterium Tuberculosis
- E.coli
- E. coli or Yeast
- Insect Cells
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- Insect Cell
- E. coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- His&Myc&SUMO
- His&GST
- GST
- Non
- N-GST
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
ADK involved in several pathways and played different roles in them. We selected most pathways ADK participated on our site, such as Metabolic pathways,Metabolism,Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of nucleotides | AK8,AK7A,ADSS,GLRX,PROZA,ADAL,DPYD,NUDT15,NUDT1,DPYS |
| Metabolism | MED16,MED6,CYP2Y3,CEPT1,NUDT3,SLC35B2,DAO1,ECI1,NDUFA11,TMEM195 |
| Purine metabolism | POLR1D,AK4,PDE6B,GMPR2,AMPD3,GUK1B,POLR3K,GC3,DGUOK,PDE4B |
| Metabolic pathways | LDHBB,mt-Atp8,SDHDA,GCLM,CKMA,NDUFA12,CKMT1A,MINPP1A,FUT9A,PIGS |
| Purine salvage | DCK,PNP5B,DGUOK,ADAL,TM9SF1,ADA |
Protein Function
ADK has several biochemical functions, for example, ATP binding,adenosine kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADK itself. We selected most functions ADK had, and list some proteins which have the same functions with ADK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | PUM1,CPEB4,MECP2,XRN2,UTP18,DHX37,RPL12,RALY,RPL4,ZAK |
| adenosine kinase activity | ADKA,ADKB |
| ATP binding | RIOK2,ERBB4A,ITPKA,CSNK1E,MCM4,CSNK2A2,STK39,MAP2K7,BBS12,MLH1 |
| metal ion binding | NPTXR,AMPD3,ZNF581,DNAJA2,RPE65A,SP5L,RPS6KAL,BAK1,CPPED1,CYP3A25 |
Interacting Protein
ADK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADK here. Most of them are supplied by our site. Hope this information will be useful for your research of ADK.
btuB;FICD;SRD5A3;15-deoxy-delta(12,14;bosutinib;imatinib;dasatinib;sch51344
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References
- Pukazhvanthen, P; Anbarasu, D; et al. Assessing humoral immune response of 4 recombinant antigens for serodiagnosis of tuberculosis. TUBERCULOSIS 94:622-633(2014).
- Cui, XA; Singh, B; et al. Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 388:46-50(2009).
