Recombinant Human ACTN1, GST-tagged

Cat.No. : ACTN1-9339H
Product Overview : Recombinant Human ACTN1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Availability March 15, 2025
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
  • Download
Species : Human
Source : E.coli
Tag : GST
Protein Length : C-term-350a.a.
Description : Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name ACTN1 actinin, alpha 1 [ Homo sapiens ]
Official Symbol ACTN1
Synonyms ACTN1; actinin, alpha 1; alpha-actinin-1; actinin 1 smooth muscle; non-muscle alpha-actinin-1; F-actin cross-linking protein; alpha-actinin cytoskeletal isoform; FLJ40884; FLJ54432;
Gene ID 87
mRNA Refseq NM_001102
Protein Refseq NP_001093
MIM 102575
UniProt ID P12814
Chromosome Location 14q24.1
Pathway Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell junction organization, organism-specific biosystem;
Function actin binding; actin filament binding; calcium ion binding; integrin binding; ion channel binding; protein binding; protein domain specific binding; vinculin binding;

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (0)

Write a review

Q&As (0)

Ask a question

Ask a Question for All ACTN1 Products

Required fields are marked with *

My Review for All ACTN1 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon