ACTN1
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Official Full Name
actinin, alpha 1 -
Overview
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ACTN1;actinin, alpha 1;BDPLT15;alpha-actinin-1;actinin 1 smooth muscle;non-muscle alpha-actinin-1;F-actin cross-linking protein;alpha-actinin cytoskeletal isoform
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- Chicken Gizzard
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ACTN1 involved in several pathways and played different roles in them. We selected most pathways ACTN1 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | CDC42L,PTPN6,EGFRA,IGF1RB,EP300,LMO7A,AASS,TGFBR1A,FGFR1,PTPRJ |
| Regulation of Actin Cytoskeleton | CFL2L,MRAS,IQGAP3,Itga10&Itgb1,ARPC5LB,PXNA,DIAP1,WASLA,PIP5K2,VAV1 |
| Focal adhesion | COL27A1A,CDC42,HRASA,GRB2B,MAPK6,ITGB1B.2,TNR,RHOAD,MYL7,COL1A1B |
| Systemic lupus erythematosus | HIST1H2BQ,SNRPB,SNRPD1,C7,ELANE,HIST1H4E,HIST1H3I,CD80,HIST2H2BB,C8G |
| Tight junction | MYL12.1,PPP2R2D,CTTN,PARD6A,HRASB,MYHC4,CASKB,PPP2R2A,CLDNG,CDC42L |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSC2,TCF7L2,CDH2,LEF1,PKP2,SGCD,TCF7,RYR2,CACNG2,ITGAV |
| Leukocyte transendothelial migration | CXCR4,CTNNA3,NCF4,PTPN11,VAV1,RAP1A,MSN,BCAR1,NCF1,VAV3 |
| Amoebiasis | PIK3R3,MUC2,SERPINB1C,COL4A4,PLCB1,ACTN4,COL4A1,ADCY1,IFNG,COL1A1 |
| Viral carcinogenesis | HIST1H4C,HIST1H4H,HIST2H2BE,HIST1H4M,DLG1,SRF,HDAC9,MRPS18B,GTF2H3,HIST1H4B |
Protein Function
ACTN1 has several biochemical functions, for example, actin filament binding,calcium ion binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN1 itself. We selected most functions ACTN1 had, and list some proteins which have the same functions with ACTN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | NPPC,DMRT2A,TPD52L2,DNM1L,SEPHS1,FGFR1OP,MECOM,MTMR2,LRRK2,LILRB1 |
| calcium ion binding | DSG1,CABP5,RCV1,DSG1C,SPARC,CAPN3A,SPOCK3,MYL6B,CD93,PLA2G2F |
| ligand-dependent nuclear receptor transcription coactivator activity | AASS,KDM1A,HELZ2,MED1,HMGA1-RS1,SRA1,PPARGC1B,CCAR1,USP22,MED17 |
| ion channel binding | CHERP,CTNNB1,YWHAQ,SCN5A,CALM1,ACTN2,CAV3,PDE4D,PKD1,HTT |
| actin filament binding | TMEM201,SHROOM3,PANX1,TAGLN3A,EZR,FMNL1,EGFR,CORO1CA,SSFA2,WIPF2 |
| integrin binding | CXADR,FBLN1,ICAM4,ACTN2,LYN,ADAM17,JAM3,ITGA5,EMP2,FN1 |
| protein binding | GP1BB,DBC1,LAMTOR3,WDR25,PTS,MKNK1,CIB3,KIAA1199,CSPP1,SERPINA3K |
| double-stranded RNA binding | YRDC,DHX15,TFRC,DDX58,DGCR8,ILF2,AGO3,TARBP2,TUBA1B,CLTC |
| vinculin binding | SORBS3,C22orf28,SYNM,PXN,DAG1,TLN1,CTNNA1,NRAP,DMD |
Interacting Protein
ACTN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN1.
p27958-pro_0000037577;CAMK2A;b2r8y4_human;OAS1;EPM2AIP1;MICALL2
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