Recombinant Human ABI1 protein, His & T7-tagged

• Cat.No.: ABI1-1704H
• Product Overview: Recombinant Human ABI1 aa. (Met1~Pro182 (Accession # Q8IZP0)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
• Source: E. coli
• Species: Human
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 24.3kDa
• Protein length: Met1~Pro182
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 9.5

Gene Information

• Gene Name: ABI1 abl interactor 1 [ Homo sapiens (human) ]
• Official Symbol: ABI1
• Synonyms: ABI1; abl interactor 1; E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1; Abelson interactor 1; Abl-interactor protein 1 long; abl-binding protein 4; eps8 SH3 domain-binding protein; interactor protein AblBP4; nap1 binding protein; spectrin SH3 domain-binding protein 1
• Gene ID: 10006
• mRNA Refseq: NM_001012750.2
• Protein Refseq: NP_001012768.1
• UniProt ID: Q8IZP0