ABI1
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Official Full Name
abl-interactor 1 -
Overview
Abelson interactor 1 (ABI1) is widely expressed with highest expression in brain. ABI1 in participation with EPS8 and SOS1?is involved in the transduction of signals from Ras to Rac. At least 10 isoforms are produced by alternative splicing. -
Synonyms
ABI1;abl-interactor 1;spectrin SH3 domain binding protein 1 , SSH3BP1;abl interactor 1;ABI 1;E3B1;Abelson interactor 1;nap1 binding protein;abl-binding protein 4;interactor protein AblBP4;Abl-interactor protein 1 long;eps8 SH3 domain-binding pr
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- T7
- DDK
- Myc
Involved Pathway
ABI1 involved in several pathways and played different roles in them. We selected most pathways ABI1 participated on our site, such as E-cadherin signaling in the nascent adherens junction,EGFR1 Signaling Pathway,ErbB1 downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | AP1S1,KIF3C,CLEC2G,NLRP4C,DEFA6,MICA,POLR3F,CLEC6A,LAT2,POLR3H |
| RHO GTPase Effectors | DIAPH1,NSL1,DSN1,NCKAP1,ROPN1,PRC1B,MKL1B,BAIAP2,SKA2,NOXO1A |
| Innate Immune System | MYO9B,TXNIP,SUGT1,PPAPDC1A,NOD1,PCBP2,WIPF2,DEFB1,CLEC5A,PANX1A |
| E-cadherin signaling in the nascent adherens junction | NCKAP1,KLHL20,WASF2,CTNND1 |
| Fcgamma receptor (FCGR) dependent phagocytosis | MYO1C,NCKIPSD,ACTR3,WIPF3,ABI2,ABI1A,ACTR2,ARPC1A,WASF2,ABI1B |
| RAC1 signaling pathway | RACGAP1,NOXA1,BAIAP2,IQGAP3,NOXO1,ABI2,NCKAP1 |
| EGFR1 Signaling Pathway | GRB7,ZPR1,CRKL,PTK6,DOK2,JUND,KLF11,EPPK1,ERRFI1,ABI1B |
| ErbB1 downstream signaling | ARF4,WASF2,MAP3K2,NCKAP1,ACTR3,CHN2,ACTR2,EGR1,EPS8,BAIAP2 |
Protein Function
ABI1 has several biochemical functions, for example, cytoskeletal protein binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABI1 itself. We selected most functions ABI1 had, and list some proteins which have the same functions with ABI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | CPS1,GNB2,BCAP31,KAT2B,RBX1,TRADD,ANKRD32,KRAS,LCK,TAPBPL |
| protein tyrosine kinase activator activity | Cd24a,GAS6,NRG1,ERCC6,ABI3A,ERBB3,ABI1B,PAK2,GHRL,AFAP1L2 |
| cytoskeletal protein binding | ALDOC,DYNLL2,EPB41L4B,EZRB,ALDOA,TOR1AIP1,FABP3,LDB3,EPB4.1L4A,ACTN2 |
| protein binding | ACTL7A,ERO1LB,OGFR,RWDD3,PDLIM4,PRDX3,C2orf28,VAMP5,CDKN2B,AIMP1 |
Interacting Protein
ABI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABI1.
ABL1;NCKAP1;WASF2
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