Recombinant Human ABCC4 Protein (M1-L1325), eGFP, Strep II, 10×His tagged

• Cat.No.: ABCC4-0103H
• Product Overview: Recombinant Human ABCC4(M1-L1325 end)-3C-eGFP-Strep II-10His Protein was expressed in Mammalian cell.

Specification

• Description: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
• Source: Mammalian cell
• Species: Human
• Tag: His&StrepII&EGFP
• Form: Liquid
• Protein length: M1-L1325
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 50 mM Tris-HCl (pH 8.5), 150 mM KCl, 2 mM DTT, 2 mM MgCL2, 0.005% (w/v) GDN
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [ Homo sapiens (human) ]
• Official Symbol: ABCC4
• Synonyms: ABCC4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; multidrug resistance-associated protein 4; bA464I2.1 (ATP binding cassette; sub family C (CFTR/MRP); member 4); canalicular multispecific organic anion transporter (ABC superfamily); EST170205; MOAT B; MOATB; MRP4; multidrug resistance associated protein 4; multispecific organic anion transporter B; MRP/cMOAT-related ABC transporter; ATP-binding cassette sub-family C member 4; multi-specific organic anion transporter B; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); MOAT-B
• Gene ID: 10257
• mRNA Refseq: NM_001105515
• Protein Refseq: NP_001098985
• MIM: 605250
• UniProt ID: O15439