Recombinant Human ABCB7 Protein, N-His-tagged

• Cat.No.: ABCB7-32H
• Product Overview: Recombinant Human ABCB7 Protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 50 mM Tris-HCl, pH 8.0, 8 M urea.
• Molecular Mass: 35.8 kDa
• AA Sequence: A DNA sequence encoding the region(Val431-End) of ABCB7
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >0.05 µg/µL as determined by microplate BCA method.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters

Gene Information

• Gene Name: ABCB7 ATP binding cassette subfamily B member 7 [ Homo sapiens (human) ]
• Official Symbol: ABCB7
• Synonyms: ABC7; ASAT; Atm1p; EST140535
• Gene ID: 22
• mRNA Refseq: NM_004299.6
• Protein Refseq: NP_004290.2
• MIM: 300135
• UniProt ID: O75027