Recombinant Full Length Human ABCB7 Protein

• Cat.No.: ABCB7-01HF
• Product Overview: Recombinant Full Length Human ABCB7 with N terminal proprietary tag; Predicted MWt 104.76 kDa.

Specification

• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol.With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis.Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 104.760kDa inclusive of tags
• Protein length: 715 amino acids
• AA Sequence: PQWRPHQLGA LGTARAYQQI PESLKSITWQ RLGKGNSGQF LDAAKALQVW PLIEKRTCWH GHAGGGLHTD PKEGLKDVDT RKIIKAMLSY VWPKDRPDLR ARVAISLGFL GGAKAMNIVV PFMFKYAVDS LNQMSGNMLN LSDAPNTVAT MATAVLIGYG VSRAGAAFFN EVRNAVFGKV AQNSIRRIAK NVFLHLHNLD LGFHLSRQTG ALSKAIDRGT RGISFVLSAL VFNLLPIMFE VMLVSGVLYY KCGAQFALVT LGTLGTYTAF TVAVTRWRTR FRIEMNKADN DAGNAAIDSL LNYETVKYFN NERYEAQRYD GFLKTYETAS LKSTSTLAML NFGQSAIFSV GLTAIMVLAS QGIVAGTLTV GDLVMVNGLL FQLSLPLNFL GTVYRETRQA LIDMNTLFTL LKVDTQIKDK VMASPLQITP QTATVAFDNV HFEYIEGQKV LSGISFEVPA GKKVAIVGGS GSGKSTIVRL LFRFYEPQKG SIYLAGQNIQ DVSLESLRRA VGVVPQDAVL FHNTIYYNLL YGNISASPEE VYAVAKLAGL HDAILRMPHG YDTQVGERGL KLSGGEKQRV AIARAILKDP PVILYDEATS SLDSITEETI LGAMKDVVKH RTSIFIAHRL STVVDADEII VLDQGKVAER GTHHGLLANP HSIYSEMWHT QSSRVQNHDN PKWEAKKENI SKEEERKKLQ EEIVNSVKGC GNCSC
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents: 0.3% Glutathione, 0.79% Tris HCl.

Gene Information

• Gene Name: ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 [ Homo sapiens ]
• Official Symbol: ABCB7
• Synonyms: ABCB7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; ABC7; ATP-binding cassette sub-family B member 7, mitochondrial; ASAT; Atm1p; EST140535
• Gene ID: 22
• mRNA Refseq: NM_004299
• Protein Refseq: NP_004290
• MIM: 300135
• UniProt ID: O75027