ABCB7
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Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 7 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] -
Synonyms
ABCB7;ATP-binding cassette, sub-family B (MDR/TAP), member 7;ABC7;ASAT;Atm1p;EST140535;ATP-binding cassette sub-family B member 7, mitochondrial;ABC transporter 7 protein;ATP-binding cassette transporter 7
Recombinant Proteins
- Mouse
- Human
- Rat
- Mus musculus
- Mammalian Cell
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- His
- GST
- His&T7
- His&Fc&Avi
- Non
Involved Pathway
ABCB7 involved in several pathways and played different roles in them. We selected most pathways ABCB7 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | SUR2A,TAP1,ABCC5,ABCC3,ABCB1,TAP2,ABCA8,ABCB9,ABCD3A,ABCA3 |
Protein Function
ABCB7 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB7 itself. We selected most functions ABCB7 had, and list some proteins which have the same functions with ABCB7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | STK26,ABCF2,NEK4,KIF16B,UBE2T,CSNK1A1L,TRIOA,NLRP4C,VARS2,GNE |
| heme transporter activity | ABCG2,HPX,SLC48A1B,SLC48A1,HRG-1,SLC48A1A,FLVCR1,MFSD7C,MFSD7B |
| ATPase activity, coupled to transmembrane movement of substances | ABCB8,ABCG2A,ATP6V1D,DPY19L2,ABCB3L1,ABCA13,ABCA1,ABCA9,ABCD2,Abcb1b |
Interacting Protein
ABCB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB7.
Kcnk1;MYC
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References
- Correa, S; Pizzatti, L; et al. A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line. PROTEOME SCIENCE 10:-(2012).
- Wong, LJC; Dimmock, D; et al. Utility of oligonucleotide array-based comparative genomic hybridization for detection of target gene deletions. CLINICAL CHEMISTRY 54:1141-1148(2008).
