Recombinant Human ABCB11 Protein, His6ABP-tagged
| Cat.No. : | ABCB11-01H |
| Product Overview : | Recombinant protein fragment of Human ABCB11 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag was expressed in E. coli. |
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| Description : | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His&ABP |
| Form : | Buffered aqueous solution |
| Molecular Mass : | 33 kDa |
| AA Sequence : | RLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILK |
| Purity : | > 80% by SDS-PAGE |
| Applications : | Suitable as a blocking agent using corresponding antibodies. |
| Usage : | The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user. |
| Storage : | At −20 centigrade. |
| Concentration : | ≥0.5 mg/mL |
| Storage Buffer : | Solution in 1 M urea-PBS, pH 7.4 |
| Shipping : | Wet ice. |
| Gene Name | ABCB11 ATP binding cassette subfamily B member 11 [ Homo sapiens (human) ] |
| Official Symbol | ABCB11 |
| Synonyms | ABCB11; ATP binding cassette subfamily B member 11; BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2; bile salt export pump; ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein |
| Gene ID | 8647 |
| mRNA Refseq | NM_003742 |
| Protein Refseq | NP_003733 |
| MIM | 603201 |
| UniProt ID | O95342 |
Not For Human Consumption!
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