ABCB11
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Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. -
Synonyms
ABCB11;ATP-binding cassette, sub-family B (MDR/TAP), member 11;bile salt export pump , BSEP, PFIC2, progressive familial intrahepatic cholestasis 2;bile salt export pump;ABC member 16;MDR/TAP subfamily;ABC16;PFIC 2;PGY4;SPGP;sister p-glycoprote
Recombinant Proteins
- Human
- Mouse
- Rat
- E. coli
- Mammalian Cell
- Sf9 Insect Cell
- E.coli
- HEK293
- N-His
- His
- Non
- His&T7
- His&ABP
- His&Fc&Avi
Involved Pathway
ABCB11 involved in several pathways and played different roles in them. We selected most pathways ABCB11 participated on our site, such as ABC transporters,Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCC6,ABCA4,ABCB6,ABCD4,ABCC4,ABCA9,ABCC10,TAP1,ABCG2,ABCB10 |
| Bile secretion | RXRA,SCARB1,NR0B2,FXYD2,SLC4A4,ATP1B3,CFTR,Abcb1b,AQP1,SLC9A1 |
Protein Function
ABCB11 has several biochemical functions, for example, ATP binding,bile acid-exporting ATPase activity,canalicular bile acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB11 itself. We selected most functions ABCB11 had, and list some proteins which have the same functions with ABCB11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RIPK4,FGR,NOD1,ATP8B1,CSNK1G1,ENTPD2,KCNJ8,ERCC2,CAMK2G,PANK1A |
| transporter activity | RLBP1B,ATP5J,TMEM184BA,TMEM184C,SEC14L4,SLC13A5A,PTGDS,AQP3A,SLC22A23,MIPA |
Interacting Protein
ABCB11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB11.
NR4A1;LY6D
Resources
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References
- Hirschfield, GM; Chapman, RW; et al. REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. GASTROENTEROLOGY 144:1357-1374(2013).
- Jungst, C; Lammert, F; et al. Cholestatic Liver Disease. DIGESTIVE DISEASES 31:152-154(2013).
