Recombinant Human ABCB1, His-tagged

• Cat.No.: ABCB1-2549H
• Product Overview: The protein was expressed as 6*his-tagged fusion protein by E. coli and Purified by Ni-sepharose.

Specification

• Cat. No.: ABCB1-2549H
• Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
• Source: E. coli
• Antigen PeptideRegion: 624-708aa
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.0) added with 100mM GSH and 1% Triton X-100,15%glycerol.
• Storage: The protein is stored in PBS buffer at -20°C. Repeated freeze-thaw cycles should be avoided.

Gene Information

• Gene Name: ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 [ Homo sapiens ]
• Official Symbol: ABCB1
• Synonyms: ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MGC163296; multidrug resistance protein 1; P-glycoprotein 1;colchicin sensitivity; doxorubicin resistance; EC 3.6.3.44
• Gene ID: 5243
• mRNA Refseq: NM_000927
• Protein Refseq: NP_000918
• MIM: 171050
• UniProt ID: P08183
• Chromosome Location: 7q21.12
• Pathway: ABC transporters; ABC-family proteins mediated transport; Bile secretion; Codeine and morphine metabolism; HIF-1-alpha transcription factor network; Nuclear receptors in lipid metabolism and toxicity; Transmembrane transport of small molecules
• Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; hydrolase activity; nucleotide binding; protein binding; transporter activity; xenobiotic-transporting ATPase activity