Recombinant Human A-kinase (PRKA) Anchor Protein 7, His-tagged

• Cat.No.: AKAP7-2395H
• Product Overview: Recombinant humanAKAP7 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: AKAP7 (A-kinaseanchor protein 7 isoform gamma isoform alpha) , also known as AKAP18, belongsto the A-kinase anchoring protein (AKAP) family, a group of functionallyrelated proteins that bind to a regulatory subunit (RII) of cAMP-dependentprotein kinase A (PKA) and target the enzyme to specific subcellularcompartments. AKAP 7 is expressed in brain, heart, lung, pancreas andskeletal muscle. AKAP 7 binds PKA to the plasma membrane, and permitsfunctional coupling to the L-type calcium channel
• Form: Liquid. In 20 mMTris-HCl buffer, pH8.0, 10% glycerol, 1mM DTT, 50mM NaCl
• Molecular Weight: 11.5kDa (105aa),confirmed by MALDI-TOF
• Purity: > 90% by SDS -PAGE
• Concentration: 1mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMGQLCC FPFSRDEGKI SEKNGGEPDD AELVRLSKRL VENAVLKAVQ QYLEETQNKNKPGEGSSVKT EAADQNGNDN ENNRK
• Storage: Stored at +4°C shortterm (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Officialsymbol: AKAP7

Gene Information

• Gene Name: AKAP7 A kinase (PRKA) anchorprotein 7 [Homo sapiens]
• Synonyms: A kinase(PRKA) anchor protein 7; A-kinase anchor protein 7; A-kinase anchor protein 7isoform alpha; A-kinase anchor protein 7 isoform gamma; Protein kinaseA-anchoring protein 7 isoform gamma; A-kinase anchor protein 7 isoforms alphaand beta; Protein kinase A-anchoring protein 7 isoforms alpha/beta; A-kinaseanchor protein 9 kDa; A-kinase anchor protein 18 kDa; A-kinase anchorprotein, 18-kD; A-kinase anchoring protein 18; protein kinase A anchoringprotein 7; AKAP15; AKAP18; AKAP 18; OTTHUMP00000017200; OTTHUMP00000017201;OTTHUMP00000017202; OTTHUMP00000239966; AKAP-7 isoform gamma; AKAP-7 isoformsalpha and beta
• Gene ID: 9465
• mRNA Refseq: NM_004842
• Protein Refseq: NP_004833
• MIM: 604693
• UniProt ID: Q6P4D3
• Chromosome Location: 6q23
• Pathway: GProtein Signaling Pathways
• Function: AMPbinding; catalytic activity; kinase activity; protein C-terminus binding;protein complex scaffold; protein domain specific binding; protein kinase Abinding; protein kinase A binding; protein kinase A regulatory subunitbinding