Recombinant Full Length Rat Patatin-Like Phospholipase Domain-Containing Protein 2(Pnpla2) Protein, His-Tagged

• Cat.No.: RFL26315RF
• Product Overview: Recombinant Full Length Rat Patatin-like phospholipase domain-containing protein 2(Pnpla2) Protein (P0C548) (1-478aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Rattus norvegicus (Rat)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-478)
• AA Sequence: MFPRETKWNISFAGCGFLGVYHIGV ASCLREHAPFLVANATHIYGASAGA LTATALVTGACLGEAGANIIEVSKE ARKRFLGPLHPSFNLVKTIRGCLLK TLPADCHTRASGRLGISLTRVSDGE NVIISHFSSKDELIQANVCSTFIPV YCGLIPPTLQGVRYVDGGISDNLPL YELKNTITVSPFSGESDICPQDSST NIHELRITNTSIQFNLRNLYRLSKA LFPPEPMVLREMCKQGYRDGLRFLR RNGLLNQPNPLLALPPVVPQEEDAE EAAVTEERTGGEDRILEHLPARLNE ALLEACVEPKDLMTTLSNMLPVRLA TAMMVPYTLPLESAVSFTIRLLEWL PDVPEDIRWMKEQTGSICQYLVMRA KRKLGDHLPSRLSEQVELRRAQSLP SVPLSCATYSEALPNWVRNNLSLGD ALAKWEECQRQLLLGLFCTNVAFPP DALRMRAPASPTATDPATPQDPSGL PPC
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: Pnpla2
• Synonyms: Pnpla2; Atgl; Patatin-like phospholipase domain-containing protein 2; Adipose triglyceride lipase
• UniProt ID: P0C548

Gene Information

• Gene Name: Pnpla2
• Synonyms: Pnpla2; Atgl; Patatin-like phospholipase domain-containing protein 2; Adipose triglyceride lipase
• UniProt ID: P0C548

Reviews

05/14/2020

Quick and precise protein expression, a valuable asset.

09/09/2019

Exceptional protein purification, highly recommended for our research.

03/01/2018

Dependable mass spectrometry analysis, enhances our proteomics research.

Q&As

How does PNPLA2 influence energy homeostasis and fatty acid oxidation in muscle tissues?

PNPLA2 influences energy homeostasis in muscles, facilitating fatty acid oxidation for energy production.

How do alterations in PNPLA2 expression or activity affect cardiovascular health and the risk of atherosclerosis?

Changes in PNPLA2 activity affect cardiovascular health, potentially influencing the development of atherosclerosis.

How does PNPLA2 contribute to the regulation of hepatic lipid metabolism and the development of fatty liver disease?

PNPLA2 regulates liver lipid metabolism, impacting the development of fatty liver disease.

What is the impact of PNPLA2 mutations on the pathogenesis of lipid storage diseases?

Mutations in PNPLA2 can lead to lipid storage diseases by disrupting normal lipid metabolism.

What role does PNPLA2 play in the development and progression of obesity and related metabolic disorders?

PNPLA2 plays a significant role in obesity and metabolic syndrome, affecting lipid storage and energy balance.

What are the mechanisms by which PNPLA2 modulates inflammation and insulin sensitivity?

PNPLA2 modulates inflammation and insulin sensitivity, influencing metabolic health and the risk of diabetes.

How does PNPLA2 regulate lipid metabolism and triglyceride hydrolysis in adipose tissue?

PNPLA2 is crucial for lipid metabolism, breaking down triglycerides in adipose tissue for energy use.