Recombinant Full Length Human TK1 Protein, C-DDK-tagged

• Cat.No.: TK1-1029HFL
• Product Overview: Recombinant Full Length Human TK1 Protein, fused to DDK-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Flag
• Description: The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers.
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 27 kDa
• AA Sequence: A DNA sequence from TrueORF clone, RC218280, encoding human full-length TK1.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism
• Full Length: Full L.

Gene Information

• Gene Name: TK1 thymidine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: TK1
• Synonyms: TK2
• Gene ID: 7083
• mRNA Refseq: NM_003258.5
• Protein Refseq: NP_003249.3
• MIM: 188300
• UniProt ID: P04183