Recombinant Full Length Human SYNJ2 Protein, C-Flag-tagged

• Cat.No.: SYNJ2-1521HFL
• Product Overview: Recombinant Full Length Human SYNJ2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 165.4 kDa
• AA Sequence: MALSKGLRLLGRLGAEGDCSVLLEA RGRDDCLLFEAGTVATLAPEEKEVI KGQYGKLTDAYGCLGELRLK SGGTSLSFLVLVTGCTSVGRIPDAE IYKITATDFYPLQEEAKEEERLIAL KKILSSGVFYFSWPNDGSRF DLTVRTQKQGDDSSEWGNSFFWNQL LHVPLRQHQVSCCDWLLKIICGVVT IRTVYASHKQAKACLVSRVS CERTGTRFHTRGVNDDGHVSNFVET EQMIYMDDGVSSFVQIRGSVPLFWE QPGLQVGSHHLRLHRGLEAN APAFDRHMVLLKEQYGQQVVVNLLG SRGGEEVLNRAFKKLLWASCHAGDT PMINFDFHQFAKGGKLEKLE TLLRPQLKLHWEDFDVFTKGENVSP RFQKGTLRMNCLDCLDRTNTVQSFI ALEVLHLQLKTLGLSSKPIV DRFVESFKAMWSLNGHSLSKVFTGS RALEGKAKVGKLKDGARSMSRTIQS NFFDGVKQEAIKLLLVGDVY GEEVADKGGMLLDSTALLVTPRILK AMTERQSEFTNFKRIRIAMGTWNVN GGKQFRSNVLRTAELTDWLL DSPQLSGATDSQDDSSPADIFAVGF EEMVELSAGNIVNASTTNKKMWGEQ LQKAISRSHRYILLTSAQLV GVCLYIFVRPYHVPFIRDVAIDTVK TGMGGKAGNKGAVGIRFQFHSTSFC FICSHLTAGQSQVKERNEDY KEITQKLCFPMGRNVFSHDYVFWCG DFNYRIDLTYEEVFYFVKRQDWKKL LEFDQLQLQKSSGKIFKDFH EGAINFGPTYKYDVGSAAYDTSDKC RTPAWTDRVLWWRKKHPFDKTAGEL NLLDSDLDVDTKVRHTWSPG ALQYYGRAELQASDHRPVLAIVEVE VQEVDVGARERVFQEVSSFQGPLDA TVVVNLQSPTLEEKNEFPED LRTELMQTLGSYGTIVLVRINQGQM LVTFADSHSALSVLDVDGMKVKGRA VKIRPKTKDWLKGLREEIIR KRDSMAPVSPTANSCLLEENFDFTS LDYESEGDILEDDEDYLVDEFNQPG VSDSELGGDDLSDVPGPTAL APPSKSPALTKKKQHPTYKDDADLV ELKRELEAVGEFRHRSPSRSLSVPN RPRPPQPPQRPPPPTGLMVK KSASDASISSGTHGQYSILQTARLL PGAPQQPPKARTGISKPYNVKQIKT TNAQEAEAAIRCLLEARGGA SEEALSAVAPRDLEASSEPEPTPGA AKPETPQAPPLLPRRPPPRVPAIKK PTLRRTGKPLSPEEQFEQQT VHFTIGPPETSVEAPPVVTAPRVPP VPKPRTFQPGKAAERPSHRKPASDE APPGAGASVPPPLEAPPLVP KVPPRRKKSAPAAFHLQVLQSNSQL LQGLTYNSSDSPSGHPPAAGTVFPQ GDFLSTSSATSPDSDGTKAM KPEAAPLLGDYQDPFWNLLHHPKLL NNTWLSKSSDPLDSGTRSPKRDPID PVSAGASAAKAELPPDHGHK
  TLGHWVTISDQEKRTALQVFDPLAK TSGPTRTRRLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Gene Information

• Gene Name: SYNJ2 synaptojanin 2 [ Homo sapiens (human) ]
• Official Symbol: SYNJ2
• Synonyms: INPP5H
• Gene ID: 8871
• mRNA Refseq: NM_003898.4
• Protein Refseq: NP_003889.1
• MIM: 609410
• UniProt ID: O15056