SYNJ2

  • Official Full Name

    synaptojanin 2

  • Overview

    The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.

  • Synonyms

    SYNJ2;synaptojanin 2;synaptojanin-2;INPP5H;Inositol phosphate 5 phosphatase 2;INPP 5H;KIAA0348;MGC44422;SJ2;Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 2;Synaptojanin2;SYNJ 2;OTTHUMP00000017494;inositol phosphate 5-phosphatase 2;synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    SYNJ2 involved in several pathways and played different roles in them. We selected most pathways SYNJ2 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYNJ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways GUK1A,ALDH1A2,GUK1B,PPT1,ALG6,MAN1A2,ALOX12B,ALPP,GALC,ADH7
    Inositol phosphate metabolism PLCD3A,MINPP1,PIKFYVE,INPP4B,PLCG2,IP6K3,PIP5K1C,PIP5K1BB,PIP5K1BA,PTENA
    Phosphatidylinositol signaling system MTMR4,MTMR3,PIP5K1C,INPP5B,PLCD3A,IPMK,PIP4K2C,PIK3CA,IP6K1,MTM1

    Protein Function

    SYNJ2 has several biochemical functions, for example, RNA binding,nucleotide binding,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYNJ2 itself. We selected most functions SYNJ2 had, and list some proteins which have the same functions with SYNJ2. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding KHDRBS3,TUT1,CTIF,THOC7,HNRNPF,TIMM50,TRIM32,MRPL3,DIS3,RNASEH1
    nucleotide binding ARL3L2,EFTUD1,HNRNPD,ERBB3B,RAB11BA,ACTC1A,ACTR2A,OXSR1B,DQX1,RAB1
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity OCRL,INPP5B,INPP5E,PTPMT1,EPM2A
    protein binding FAM133A,CRK,FAM20C,INTS4,TNFAIP8,PPIAL4A,HTRA3,NVL,SEPSECS,GPR85

    Interacting Protein

    SYNJ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYNJ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYNJ2.

    GRB2;PARP2;ABL1;FYN;NCK1;PIK3R1;SFN;SH3KBP1;RAC1;ITSN2

    Resources

    References

    • Ru, YW; Yin, L; et al. A micropreparation of mitochondria from cells using magnetic beads with immunoaffinity. ANALYTICAL BIOCHEMISTRY 421:219-226(2012).
    • Roesli, C; Borgia, B; et al. Comparative Analysis of the Membrane Proteome of Closely Related Metastatic and Nonmetastatic Tumor Cells. CANCER RESEARCH 69:5406-5414(2009).

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