Recombinant Full Length Human SMARCA4 Protein, C-His,C-Flag-tagged

• Cat.No.: SMARCA4-01HFL
• Product Overview: Recombinant Full Length Human SMARCA4 Protein, fused to His and Flag-tag at C-terminus, was expressed in Baculovirus.

Specification

• Description: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cells
• Species: Human
• Tag: C-His,C-Flag
• Form: Sterile 25mM Hepes, 0.1mM EDTA, 10% Glycerol, 350mM NaCl, pH7.6.
• Molecular Mass: 186 kDa
• AA Sequence: MSTPDPPLGGTPRPGPSPGPGPSPG AMLGPSPGPSPGSAHSMMGPSPGPP SAGHPIPTQGPGGYPQDNMHQMHKP MESMHEKGMSDDPRYNQMKGMGMRS GGHAGMGPPPSPMDQHSQGYPSPLG GSEHASSPVPASGPSSGPQMSSGPG GAPLDGADPQALGQQNRGPTPFNQN QLHQLRAQIMAYKMLARGQPLPDHL QMAVQGKRPMPGMQQQMPTLPPPSV SATGPGPGPGPGPGPGPGPAPPNYS RPHGMGGPNMPPPGPSGVPPGMPGQ PPGGPPKPWPEGPMANAAAPTSTPQ KLIPPQPTGRPSPAPPAVPPAASPV MPPQTQSPGQPAQPAPMVPLHQKQS RITPIQKPRGLDPVEILQEREYRLQ ARIAHRIQELENLPGSLAGDLRTKA TIELKALRLLNFQRQLRQEVVVCMR RDTALETALNAKAYKRSKRQSLREA RITEKLEKQQKIEQERKRRQKHQEY LNSILQHAKDFKEYHRSVTGKIQKL TKAVATYHANTEREQKKENERIEKE RMRRLMAEDEEGYRKLIDQKKDKRL AYLLQQTDEYVANLTELVRQHKAAQ VAKEKKKKKKKKKAENAEGQTPAIG PDGEPLDETSQMSDLPVKVIHVESG KILTGTDAPKAGQLEAWLEMNPGYE VAPRSDSEESGSEEEEEEEEEEQPQ AAQPPTLPVEEKKKIPDPDSDDVSE VDARHIIENAKQDVDDEYGVSQALA RGLQSYYAVAHAVTERVDKQSALMV NGVLKQYQIKGLEWLVSLYNNNLNG ILADEMGLGKTIQTIALITYLMEHK RINGPFLIIVPLSTLSNWAYEFDKW APSVVKVSYKGSPAARRAFVPQLRS GKFNVLLTTYEYIIKDKHILAKIRW KYMIVDEGHRMKNHHCKLTQVLNTH YVAPRRLLLTGTPLQNKLPELWALL NFLLPTIFKSCSTFEQWFNAPFAMT GEKVDLNEEETILIIRRLHKVLRPF LLRRLKKEVEAQLPEKVEYVIKCDM SALQRVLYRHMQAKGVLLTDGSEKD KKGKGGTKTLMNTIMQLRKICNHPY MFQHIEESFSEHLGFTGGIVQGLDL YRASGKFELLDRILPKLRATNHKVL LFCQMTSLMTIMEDYFAYRGFKYLR LDGTTKAEDRGMLLKTFNEPGSEYF IFLLSTRAGGLGLNLQSADTVIIFD SDWNPHQDLQAQDRAHRIGQQNEVR VLRLCTVNSVEEKILAAAKYKLNVD QKVIQAGMFDQKSSSHERRAFLQAI LEHEEQDESRHCSTGSGSASFAHTA PPPAGVNPDLEEPPLKEEDEVPDDE TVNQMIARHEEEFDLFMRMDLDRRR EEARNPKRKPRLMEEDELPSWIIKD DAEVERLTCEEEEEKMFGRGSRHRK EVDYSDSLTEKQWLKAIEEGTLEEI EEEVRQKKSSRKRKRDSDAGSSTPT TSTRSRDKDDESKKQKKRGRPPAEK LSPNPPNLTKKMKKIVDAVIKYKDS SSGRQLSEVFIQLPSRKELPEYYEL IRKPVDFKKIKERIRNHKYRSLNDL EKDVMLLCQNAQTFNLEGSLIYEDS IVLQSVFTSVRQKIEKEDDSEGEES EEEEEGEEEGSESESRSVKVKIKLG RKEKAQDRLKGGRRRPSRGSRAKPV VSDDDSEEEQEEDRSGSGSEEDHHH HHHDYKDDDDK
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.46 mg/ml

Gene Information

• Gene Name: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [ Homo sapiens (human) ]
• Official Symbol: SMARCA4
• Synonyms: SMARCA4; BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
• Gene ID: 6597
• mRNA Refseq: NM_003072.5
• Protein Refseq: NP_003063.2
• MIM: 603254
• UniProt ID: P51532

Reviews

02/18/2023

The SMARCA4 protein offers exceptional quality that meets the rigorous demands of experimental research.

11/01/2018

It exhibits exceptional performance in ELISA assays, making it an excellent choice for researchers studying angiopoietins, angiogenesis, or vascular biology.

10/30/2016

Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.

Q&As

Can epigenetic therapies target SMARCA4 alterations?

Epigenetic therapies that modulate gene expression could indirectly affect SMARCA4-altered cancers, though specific targeting remains a challenge.

Are there diagnostic tests for SMARCA4 mutations?

Yes, there are genetic tests available to identify SMARCA4 mutations in tumors, aiding in prognosis and treatment decisions.

Are there ongoing clinical trials focusing on SMARCA4 alterations?

Yes, there are clinical trials exploring new treatment strategies for SMARCA4-altered cancers, aiming to improve patient outcomes.

Is SMARCA4 solely associated with cancer?

No, SMARCA4's functions extend beyond cancer and have implications in various biological processes, including development and differentiation.

How can SMARCA4 mutations influence patient prognosis?

Patients with SMARCA4 mutations in their tumors often face a poorer prognosis, which necessitates tailored treatment approaches.