Recombinant Full Length Human PSPH protein, His-tagged

• Cat.No.: PSPH-202H
• Product Overview: Recombinant Human PSPH(Met1-Glu225) fused with His tag at C-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-225 a.a.
• Description: Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.
• Form: Liquid
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Storage: Store at < -20 centigrade, stable for 6 months after receipt.Please minimize freeze-thaw cycles.

Gene Information

• Gene Name: PSPH phosphoserine phosphatase [ Homo sapiens ]
• Official Symbol: PSPH
• Synonyms: PSPH; phosphoserine phosphatase; PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; PSPHD
• Gene ID: 5723
• mRNA Refseq: NM_004577
• Protein Refseq: NP_004568
• MIM: 172480
• UniProt ID: P78330
• Chromosome Location: 7p11.2
• Pathway: Amino acid synthesis and interconversion (transamination), organism-specific biosystem; Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Serine biosynthesis, organism-specific biosystem
• Function: calcium ion binding; hydrolase activity; magnesium ion binding; phosphoserine phosphatase activity; phosphoserine phosphatase activity; protein homodimerization activity