Recombinant Full Length Human Protein Kinase C, Iota, His-tagged

Cat. No. :

PRKCI-1303H

Description :

The PKCfamily of serine/threonine kinases, including PRKCI, is activatedintracellularly by signal transduction pathways. In humans, at least 12different PKC polypeptides have been identified. These isoforms differ inprimary structure, tissue distribution, subcellular localization, mode ofaction in vitro, response to extracellular signals, and substratespecificity. PKC alpha, beta I, beta II and gamma form the conventional family;their activities are Ca2+ and phospholipiddependent. No specialmeasures were taken to activate this kinase.

Source :

Insect cells

Species :

Human

Form :

Liquid in20 mM HEPES, pH 7.5 + 150 mM NaCl + 0.5 mM EGTA + 0.5 mM EDTA + 0.05% NP-40 +5 mM DTT + 50% glycerol.

Storage :

Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.

OfficialSymbol :

PRKCI

nullValue_other :

Function

ATP binding; nucleotide binding;protein binding; protein kinase activity; protein serine/threonine kinaseactivity; zinc ion binding; metal ion binding; histone kinase activity (H3-T6specific); phospholopid binding

Protein length :

1-596 a.a.

Full Length :

Full L.

Gene Name	PRKCI protein kinase C, iota [ Homosapiens ]
Synonyms	PRKCI; proteinkinase C, iota; PKCI; DXS1179E; MGC26534; nPKC-iota; OTTHUMP00000196630;Proteinkinase C iota type; Atypical protein kinase C-lambda/iota; PRKC-lambda/iota; aPKC-iota;EC 2.7.11.13
Gene ID	5584
mRNA Refseq	NM_002740
Protein Refseq	NP_002741
MIM	600539
UniProt ID	P41743
Chromosome Location	3q26.3
Pathway	Celljunction organization; EGFR1 Signaling Pathway; Endocytosis; G ProteinSignaling Pathways; IL-4 signaling Pathway; IL1-mediated signaling events; Insulin-mediatedglucose transport; Neurotrophic factor-mediated Trk receptor signaling;Signal Transduction; Signalling by NGF; TNF receptor signaling pathway; Tightjunction; Wnt Signaling Pathway; p75 NTR receptor-mediated signalling

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