Recombinant Full Length Human presenilin enhancer, gamma-secretase subunit Protein, Flag tagged

• Cat.No.: PSENEN-33HFL
• Product Overview: Recombinant protein of human presenilin enhancer 2 homolog (C. elegans) (PSENEN) with C-Myc/DDK tag was expressed in HEK293.

Specification

• Description: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: C-Flag
• Protein length: 1-101aa
• Molecular Mass: 11.8 kDa
• AA Sequence: MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: > 0.05 μg/μL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.

Gene Information

• Gene Name: PSENEN presenilin enhancer, gamma-secretase subunit [ Homo sapiens (human) ]
• Official Symbol: PSENEN
• Synonyms: PSENEN; presenilin enhancer, gamma-secretase subunit; PEN2; PEN-2; MDS033; ACNINV2; MSTP064; gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; presenilin enhancer 2 homolog
• Gene ID: 55851
• mRNA Refseq: NM_172341
• Protein Refseq: NP_758844
• MIM: 607632
• UniProt ID: Q9NZ42