PSENEN
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Official Full Name
presenilin enhancer gamma secretase subunit -
Overview
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimers disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] -
Synonyms
PSENEN;presenilin enhancer gamma secretase subunit;PEN2;PEN-2;MDS033;MSTP064;gamma-secretase subunit PEN-2;presenilin enhancer 2 homolog;hematopoietic stem/progenitor cells protein MDS033
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Dictyostelium Discoideum
- Mus musculus
- Bovine
- E.coli
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- HEK293T
- E.coli expression system
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PSENEN involved in several pathways and played different roles in them. We selected most pathways PSENEN participated on our site, such as Notch signaling pathway,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSENEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | HER9,DTX4,MFNG,NOTCH4,TUBB3,LFNG,MFAP5,DLA,KAT2A,EP300 |
| Alzheimers disease | ERN1,CALML3,NDUFB5,COX8A,CAPN2,MAPK3,UQCRB,NDUFS1,ATP5D,MT-ATP6 |
Protein Function
PSENEN has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSENEN itself. We selected most functions PSENEN had, and list some proteins which have the same functions with PSENEN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZW10,NARG2,MAGEA11,NFKB1,USP8,AIPL1,GPS2,C5orf24,PSMB8,EBF1 |
Interacting Protein
PSENEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSENEN here. Most of them are supplied by our site. Hope this information will be useful for your research of PSENEN.
NCSTN;FTL;TMED10;CREB3;THBD;APH1A
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