Recombinant Full Length Human MRVI1 Protein

• Cat.No.: MRVI1-6535HF
• Product Overview: Human MRVI1 full-length ORF (ADR83074.1) recombinant protein without tag.

Specification

• Description: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during lymphoid differentiation. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, few of which initiate translation at a non-AUG (CUG) start site. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 65.7 kDa
• Protein length: 187 amino acids
• AA Sequence: MALNSPQPGPVESELGKQLLKTGWEGSPLPRSPTQDAAGVGPPASQGRGPAGEPMGPEAGSKAELPPTVSRPPLLRGLSWDSGPEEPGPRLQKVLAKLPLAEEEKRFAGKAGGKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGLKLPDLSEAAEQEKGLPSELSPAIEEEESKSGLDVMPNISDVLLRKLRVHRSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTLGKNMPRRRVSVAVVPKFNALNLPGQTPSSSSIPSLPALSESPNGKGSLPVTSALPALLENGKTNGDPDCEASAPALTLSCLEELSQETKARMEEEAYSKGFQEGLKKTKELQDLKEEEEEQKSESPEEPEEVEETEEEEKGPRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLTVVLGLYNSYNSCAEQADGPLGRSTCSAAQRDSWWSSGLQHEQPTEQ
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: MRVI1 murine retrovirus integration site 1 homolog [ Homo sapiens ]
• Official Symbol: MRVI1
• Synonyms: MRVI1; murine retrovirus integration site 1 homolog; protein MRVI1; inositol 1; 4; 5 triphosphate associated cGMP kinase substrate; IP3R associated cGMP kinase substrate; IRAG; JAW1L; JAW1-related protein MRVI1; IP3R-associated cGMP kinase substrate; inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate; inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
• Gene ID: 10335
• mRNA Refseq: NM_001098579
• Protein Refseq: NP_001092049
• MIM: 604673
• UniProt ID: Q9Y6F6