MRVI1
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Official Full Name
murine retrovirus integration site 1 homolog -
Overview
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. -
Synonyms
MRVI1;murine retrovirus integration site 1 homolog;protein MRVI1;inositol 1;4;5 triphosphate associated cGMP kinase substrate;IP3R associated cGMP kinase substrate;IRAG;JAW1L;JAW1-related protein MRVI1;IP3R-associated cGMP kinase substrate;inos
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| MRVI1-1939H | Recombinant Human MRVI1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| MRVI1-2738H | Recombinant Human MRVI1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| MRVI1-5631H | Recombinant Human MRVI1 Protein | Wheat Germ | Human | Non |
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| MRVI1-6535HF | Recombinant Full Length Human MRVI1 Protein | In Vitro Cell Free System | Human | Full L. 187 amino acids |
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Involved Pathway
MRVI1 involved in several pathways and played different roles in them. We selected most pathways MRVI1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MRVI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
MRVI1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MRVI1 itself. We selected most functions MRVI1 had, and list some proteins which have the same functions with MRVI1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
MRVI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRVI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRVI1.
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References
- Fujino, Y; Liao, CP; et al. Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma. VIROLOGY 386:16-22(2009).
- Studamire, B; Goff, SP; et al. Host proteins interacting with the Moloney murine leukemia virus integrase: Multiple transcriptional regulators and chromatin binding factors. RETROVIROLOGY 5:-(2008).
