Recombinant Full Length Human HNMT Protein, GST-tagged

• Cat.No.: HNMT-3677HF
• Product Overview: Human HNMT full-length ORF ( AAH05907, 1 a.a. - 51 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 31.35 kDa
• Protein length: 51 amino acids
• AA Sequence: MASSMRSLFSDHGKYVESFRRFLNH STEHQCMQEFMDKKLPGIIGRYQNC C
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HNMT histamine N-methyltransferase [ Homo sapiens ]
• Official Symbol: HNMT
• Synonyms: HNMT; histamine N-methyltransferase; HMT; HNMT-S1; HNMT-S2
• Gene ID: 3176
• mRNA Refseq: NM_001024074
• Protein Refseq: NP_001019245
• MIM: 605238
• UniProt ID: P50135

Reviews

03/21/2018

HNMT protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.

01/17/2018

Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.

02/26/2017

Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the HNMT protein.

Q&As

Is there a link between HNMT and gastrointestinal disorders?

Yes, HNMT dysfunction has been associated with gastrointestinal disorders, and understanding its role may open avenues for novel therapeutic strategies.

In what ways does HNMT play a role in the nervous system?

HNMT is involved in the inactivation of histamine in the central nervous system, influencing neurotransmission and potentially impacting conditions like schizophrenia and anxiety disorders.

Can HNMT be used as a predictive marker for treatment response in certain conditions?

Research is underway to investigate whether HNMT levels or activity could serve as predictive markers for treatment response in conditions where histamine regulation is implicated.

How does HNMT relate to drug metabolism and interactions?

HNMT is involved in the metabolism of certain drugs, and variations in its activity can influence drug responses and potential interactions.

Can HNMT be a target for cancer therapy?

Some studies suggest that HNMT may play a role in certain cancers, making it a potential target for therapeutic interventions. However, more research is needed in this area.