Recombinant Full Length Human HNF4A Protein, GST-tagged

• Cat.No.: HNF4A-3676HF
• Product Overview: Human HNF4A full-length ORF ( NP_849180.1, 1 a.a. - 464 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 78 kDa
• Protein length: 464 amino acids
• AA Sequence: MRLSKTLVDMDMADYSAALDPAYTT LEFENVQVLTMGNDTSPSEGTNLNA PNSLGVSALCAICGDRATGKHYGAS SCDGCKGFFRRSVRKNHMYSCRFSR QCVVDKDKRNQCRYCRLKKCFRAGM KKEAVQNERDRISTRRSSYEDSSLP SINALLQAEVLSRQITSPVSGINGD IRAKKIASIADVCESMKEQLLVLVE WAKYIPAFCELPLDDQVALLRAHAG EHLLLGATKRSMVFKDVLLLGNDYI VPRHCPELAEMSRVSIRILDELVLP FQELQIDDNEYAYLKAIIFFDPDAK GLSDPGKIKRLRSQVQVSLEDYIND RQYDSRGRFGELLLLLPTLQSITWQ MIEQIQFIKLFGMAKIDNLLQEMLL GGSPSDAPHAHHPLHPHLMQEHMGT NVIVANTMPTHLSNGQMSTPETPQP SPPGGSGSEPYKLLPGAVATIVKPL SAIPQPTITKQEVI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HNF4A hepatocyte nuclear factor 4, alpha [ Homo sapiens ]
• Official Symbol: HNF4A
• Synonyms: HNF4A; hepatocyte nuclear factor 4, alpha; MODY, MODY1, TCF14; hepatocyte nuclear factor 4-alpha; HNF4; NR2A1; TCF-14; HNF-4-alpha; HNF4alpha10/11/12; transcription factor 14; transcription factor-14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; TCF; MODY; MODY1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha; FLJ39654
• Gene ID: 3172
• mRNA Refseq: NM_000457
• Protein Refseq: NP_000448
• MIM: 600281
• UniProt ID: P41235