Recombinant Human HNF4A Protein, His-tagged

• Cat.No.: HNF4A-630H
• Product Overview: Recombinant Human HNF4A(Gln131~Ser330) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 26.5kDa
• Identity: Reconstitute in PBS or others
• Protein length: Gln131~Ser330
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: HNF4A hepatocyte nuclear factor 4, alpha [ Homo sapiens ]
• Official Symbol: HNF4A
• Synonyms: HNF4A; hepatocyte nuclear factor 4, alpha; MODY, MODY1, TCF14; hepatocyte nuclear factor 4-alpha; HNF4; NR2A1; TCF-14; HNF-4-alpha; HNF4alpha10/11/12; transcription factor 14; transcription factor-14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; TCF; MODY; MODY1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha; FLJ39654
• Gene ID: 3172
• mRNA Refseq: NM_000457
• Protein Refseq: NP_000448
• MIM: 600281
• UniProt ID: P41235