Recombinant Full Length Human HAAO Protein, GST-tagged

• Cat.No.: HAAO-3415HF
• Product Overview: Human HAAO full-length ORF ( AAH29510.1, 1 a.a. - 286 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 59 kDa
• Protein length: 286 amino acids
• AA Sequence: MERRLGVRAWVKENRGSFQPPVCNK LMHQEQLKVMFIGGPNTRKDYHIEE GEEVFYQLEGDMVLRVLEQGKHRDV VIRQGEIFLLPARVPHSPQRFANTV GLVVERRRLETELDGLRYYVGDTMD VLFEKWFYCKDLGTQLAPIIQEFFS SEQYRTGKPIPDQLLKEPPFPLSTR SIMEPMSLDAWLDSHHRELQAGTPL SLFGDTYETQVIAYGQGSSEGLRQN VDVWLWQLEGSSVVTMGGRRLSLAP DDSLLVLAGTSYAWERTQGSVALSV TQDPACKKPLG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HAAO 3-hydroxyanthranilate 3,4-dioxygenase [ Homo sapiens ]
• Official Symbol: HAAO
• Synonyms: HAAO; 3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAO; 3-HAO
• Gene ID: 23498
• mRNA Refseq: NM_012205
• Protein Refseq: NP_036337
• MIM: 604521
• UniProt ID: P46952