Recombinant Full Length Human GAB3 Protein, GST-tagged

• Cat.No.: GAB3-5147HF
• Product Overview: Human GAB3 full-length ORF ( NP_542179.1, 1 a.a. - 586 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 92 kDa
• Protein length: 586 amino acids
• AA Sequence: MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSGSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]
• Official Symbol: GAB3
• Synonyms: GAB3; GRB2 associated binding protein 3; GRB2-associated-binding protein 3; DOS/Gab family member 3; GRB2-associated binder 3; Gab3 scaffolding protein; growth factor receptor bound protein 2-associated protein 3; GRB2 Associated Binding Protein 3; Growth Factor Receptor Bound Protein 2-Associated Protein 3; Gab3 Scaffolding Protein; GRB2-Associated Binder 3; DOS/Gab Family Member 3
• Gene ID: 139716
• mRNA Refseq: NM_001081573
• Protein Refseq: NP_001075042
• MIM: 300482
• UniProt ID: Q8WWW8