Recombinant Full Length Human CASP4 Protein, N-His-tagged

• Cat.No.: CASP4-921HFL
• Product Overview: Recombinant Full Length Human CASP4 Protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 43.1 kDa
• AA Sequence: A DNA sequence encoding human full-length CASP4.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease
• Full Length: Full L.

Gene Information

• Gene Name: CASP4 caspase 4 [ Homo sapiens (human) ]
• Official Symbol: CASP4
• Synonyms: TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II
• Gene ID: 837
• mRNA Refseq: NM_001225.4
• Protein Refseq: NP_001216.1
• MIM: 602664
• UniProt ID: P49662