CASP4
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Official Full Name
caspase 4, apoptosis-related cysteine peptidase -
Overview
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. -
Synonyms
Apoptosis related cysteine peptidase;Apoptotic cysteine protease Mih1/TX;CASP 4;CASP-4;CASP4;CASP4_HUMAN;Caspase-4 subunit 2;Caspase4;ICE(rel) II;ICE(rel)-II;ICE(rel)II;ICEREL II;ICERELII;ICH 2;Mih1/TX;Protease ICH-2;Protease TX;TX;TX protease;OTTHUMP00000231863;OTTHUMP00000231864;caspase 4, apoptosis-related cysteine protease;EC 3.4.22.57;EC 3.4.22
Recombinant Proteins
- Human
- Cattle
- Mouse
- Rhesus macaque
- Rat
- Arabidopsis thaliana
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- Non
- His
- GST
- His&Fc&Avi
Involved Pathway
CASP4 involved in several pathways and played different roles in them. We selected most pathways CASP4 participated on our site, such as Apoptosis,Caspase cascade in apoptosis,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Innate Immune System | BTR29,BTR09,RNF216,TAX1BP1,CD300LB,TNIP2,SIGLEC14,NOD1,KIR3DS1,KIR2DS2 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | BTR16,TXNIPA,BTR12,PANX1B,NLRP3,BTR06,BTR30,SUGT1,PANX1,BTR22 |
| Caspase cascade in apoptosis | SATB1,TOP1,GAS2,TFAP2A,CRADD,LMNB1,NUMA1,DFFA,ACTA1,DIABLO |
| NOD1/2 Signaling Pathway | CYLD |
| Immune System | SPSB1,IFIT8,TNFSF13B,IRF2,RNF19B,SPSB2,TRIM10,TREX1,KIF15,LAT2 |
| Apoptosis | MYC,PTBP3,IRF2A,DSG1,CASP8L1,H1F0,CASP6,MYD88,BAX,SATB1 |
Protein Function
CASP4 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP4 itself. We selected most functions CASP4 had, and list some proteins which have the same functions with CASP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis | PSD,CASP12,CASPBL,CASPA,CASP5,CASPB,CASP1 |
Interacting Protein
CASP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP4.
COPE;SNRNP200;UFL1;SMC2;GSN;SNRPA1;UMPS;PSMB1;VDAC1;CDK2;EIF2S3;SSR4;MSH6;SLC25A1;UBXN1;DCTN1;SMC1A;PSMD6;MTHFD1L
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