Recombinant Full Length Human BCL2L2 Protein, C-Flag-tagged

• Cat.No.: BCL2L2-1821HFL
• Product Overview: Recombinant Full Length Human BCL2L2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 20.6 kDa
• AA Sequence: MATPASAPDTRALVADFVGYKLRQK GYVCGAGPGEGPAADPLHQAMRAAG DEFETRFRRTFSDLAAQLHV TPGSAQQRFTQVSDELFQGGPNWGR LVAFFVFGAALCAESVNKEMEPLVG QVQEWMVAYLETRLADWIHS SGGWAEFTALYGDGALEEARRLREG NWASVRTVLTGAVALGALVTVGAFF ASK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane

Gene Information

• Gene Name: BCL2L2 BCL2 like 2 [ Homo sapiens (human) ]
• Official Symbol: BCL2L2
• Synonyms: BCLW; BCL-W; PPP1R51; BCL2-L-2
• Gene ID: 599
• mRNA Refseq: NM_004050.5
• Protein Refseq: NP_004041.2
• MIM: 601931
• UniProt ID: Q92843