Recombinant Full Length Human ATF4 Protein, N-His-tagged

• Cat.No.: ATF4-217HFL
• Product Overview: Recombinant Full Length Human ATF4 Protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 38.4 kDa
• AA Sequence: A DNA sequence encoding human full-length ATF4.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Protein Families: Transcription Factors
• Protein Pathways: GnRH signaling pathway, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Prostate cancer
• Full Length: Full L.

Gene Information

• Gene Name: ATF4 activating transcription factor 4 [ Homo sapiens (human) ]
• Official Symbol: ATF4
• Synonyms: CREB2; TXREB; CREB-2; TAXREB67
• Gene ID: 468
• mRNA Refseq: NM_001675.4
• Protein Refseq: NP_001666.2
• MIM: 604064
• UniProt ID: P18848