Recombinant Full Length Human ACMSD Protein, GST-tagged

• Cat.No.: ACMSD-779HF
• Product Overview: Human ACMSD full-length ORF ( AAH16018.1, 1 a.a. - 278 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: In Vitro Cell Free System
• Tag: GST
• Protein Length: 278 amino acids
• Description: The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
• Molecular Mass: 57.6 kDa
• AA Sequence: MGKSSEWCER IAGIQKFVLE KWTKKAKPED TLNLCQLLNN DLASTVVSYP RRFVGLGTLP MQAPELAVKE MERCVKELGF PGVQIGTHVN EWDLNAQELF PVYAAAERLK CSLFVHPWDM QMDGRMAKYW LPWLVGMPAE TTIAICSMIM GGVFEKFPKL KVCFAHGGGA FPFTVGRISH GFSMRPDLCA QDNPMNPKKY LGSFYTDALV HDPLSLKLLT DVIGKDKVIL GTDYPFPLGE LEPGKLIESM EEFDEETKNK LKAGNALAFL GLERKQFE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACMSD aminocarboxymuconate semialdehyde decarboxylase [ Homo sapiens ]
• Official Symbol: ACMSD
• Synonyms: ACMSD; aminocarboxymuconate semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
• Gene ID: 130013
• mRNA Refseq: NM_138326
• Protein Refseq: NP_612199
• MIM: 608889
• UniProt ID: Q8TDX5