ACMSD
-
Official Full Name
aminocarboxymuconate semialdehyde decarboxylase -
Overview
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. -
Synonyms
ACMSD;aminocarboxymuconate semialdehyde decarboxylase;2-amino-3-carboxymuconate-6-semialdehyde decarboxylase;2 amino 3 carboxymuconate 6 semialdehyde decarboxylase;Picolinate carboxylase;OTTHUMP00000162500;OTTHUMP00000162501
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E.coli
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
ACMSD involved in several pathways and played different roles in them. We selected most pathways ACMSD participated on our site, such as 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA,Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism,L-kynurenine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACMSD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | IDO2,AFMID,SLC25A21,UROC1,PCBD1,DLST,CRYM,AMDHD1,FTCD |
| Metabolic pathways | SAT2,CHIA.2,MDH2,PLD2,MAN1A1,TKTB,FLAD1,DPM3,SPHK2,ATP5C1 |
| Metabolism of amino acids and derivatives | CKBA,BHMT2,LSM1,CKMB,NQO1,DBH,CKMT2A,SLC25A15B,AHCY,OAZ2B |
| L-kynurenine degradation | AFMID,IDO2 |
| Metabolism | AWAT2,GYG1A,SLC25A10,COQ7,PPM1LA,OXSR1,CTRC,PEMT,MED29,SLC27A2 |
Protein Function
ACMSD has several biochemical functions, for example, aminocarboxymuconate-semialdehyde decarboxylase activity,hydrolase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACMSD itself. We selected most functions ACMSD had, and list some proteins which have the same functions with ACMSD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | KEL,SALL4,ZNF653,IRF2BP2A,TIMM8A2,ZNF43,ZFP335,ZNF703,ZFP35,ESCO1 |
| protein binding | SULT1C2,FGF7,CYTIP,CRY1A,STK24,IFNA2,NMU,LAT2,ETV1,TXNIP |
| hydrolase activity | MCPT1,UFSP2,DHX57,FAM49BA,INPP5KA,DAGLB,CAPN3A,ENOPH1,PSMA6A,IRGC |
Interacting Protein
ACMSD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACMSD here. Most of them are supplied by our site. Hope this information will be useful for your research of ACMSD.
MAGEA11;PLIN3;MAGEA11
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