Recombinant Equine Interleukin 13

• Cat.No.: IL13-252E
• Product Overview: Recombinant Equine IL-13 was expressed inYeast. MW= 12.6 kDa (115 aa).

Specification

• Species: Equine
• Source: Yeast
• Tag: Non
• Description: IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: SPAPLPSSMA LKELIKELVN ITQNQAPLCN GSMVWSVNLT ADTYCRALES LSNVSTCSAI QNTRKMLTKL CPHQLSAGQV SSERARDTKI EVIVLVKDLL KNLRKIFHGG KHVDA.
• Bioactivity: In testing.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: IL-13 interleukin-13 [ Equus caballus ]
• Synonyms: interleukin-13; IL-13
• Gene ID: 100034113
• mRNA Refseq: NM_001143791.1
• Protein Refseq: NP_001137263.1
• Chromosome Location: 14
• Pathway: Asthma; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Jak-STAT signaling pathway