Recombinant Dog Calnexin

• Cat.No.: CANX-2072D
• Product Overview: Recombinant Dog Calnexin is produced inHEK 293 Cell.

Specification

• Species: Dog
• Source: HEK293
• Tag: Non
• Description: Calnexin (CNX) is a 90 kDa integral protein of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. Calnexin is one of the chaperone molecules, which are characterized by their main function of assisting protein folding and quality control, ensuring that only properly folded and assembled proteins proceed further along the secretory pathway. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin binds only those N-glycoproteins that have GlcNAc2Man9Glc1 oligosaccharides. Oligosaccharides with three sequential glucose residues are added to asparagine residues of the nascent proteins in the ER.
• Concentration: 0.5mg/ml.
• Formulation: Liquid. In 40mM HEPES, pH 7.5, containing 150mM sodium chloride, 5mM calcium chloride.
• Purity: ≥99% (SDS-PAGE; MS).
• Application: Western Blot.
• Storage: -80°C. Avoid freeze/thaw cycles. Short term storage: +4°C.

Gene Information

• Gene Name: CANX calnexin [ Canis lupus familiaris ]
• Synonyms: CANX; calnexin; PP90
• Gene ID: 403908
• mRNA Refseq: NM_001003232
• Protein Refseq: NP_001003232
• UniProt ID: P24643
• Chromosome Location: 11
• Pathway: Antigen processing and presentation