Recombinant Chicken TGFB2 Protein, His-tagged

• Cat.No.: TGFB2-1252C
• Product Overview: Recombinant Chicken TGFB2 Protein (Leu279-Ser412) with His tag was expressed in E. coli.

Specification

• Species: Chicken
• Source: E.coli
• Tag: His
• Protein Length: Leu279-Ser412
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 19.1 kDa; Accurate Molecular Mass: 19 kDa
• Purity: > 90%
• Applications: Cell culture; Activity Assays.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: TGFB2 transforming growth factor beta 2 [ Gallus gallus (chicken) ]
• Official Symbol: TGFB2
• Synonyms: TGFB2; transforming growth factor beta 2; TGF-beta-2; transforming growth factor beta-2 proprotein; TGF beta2; transforming growth factor-beta2
• Gene ID: 421352
• mRNA Refseq: NM_001031045
• Protein Refseq: NP_001026216
• UniProt ID: P30371