Recombinant C. difficile tcdB Protein

• Cat.No.: tcdB-007C
• Product Overview: Recombinant Clostridioides difficile tcdB protein without tag was expressed in E.coli

Specification

• Species: C.difficile
• Source: E.coli
• Description: Toxin B from Clostridium difficile, also known as TcdB, is a cytotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion. Toxin B can induce activation of the inflammasome and apoptosis. While both toxin A and toxin B inactivate Rho family GTPases, toxin B more potently induces mammalian cell rounding in culture.
• Purity: ≥90% estimated by SDS-PAGE
• Stability: ≥ 2 years
• Storage: 2 to 8 centigrade
• Concentration: 0.2 mg/ml
• Storage Buffer: Each vial contains 50 μg of C. difficile toxin B in 50 mM Tris, 100 mM NaCl, pH 7.5
• Shipping: Room Temperature in continental US, may vary elsewhere.

Gene Information

• Gene Name: tcdB glycosylating toxin TcdB [ Clostridioides difficile ]
• Official Symbol: tcdB
• Synonyms: tcdB; glycosylating toxin TcdB; toxB; glycosylating toxin TcdB
• Gene ID: 31352216
• UniProt ID: P18177