Rat Anti-Timd2 Monoclonal Antibody

• Cat.No.: DMAB36387
• Product Overview: Rat Anti-Timd2 Monoclonal Antibody

Specification

• Species: Mouse
• Source: Rat
• Tag: Non
• Antigen Description: Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.
• specificity: It specifically recognises mouse Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells.
• Target: Timd2
• Immunogen: Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a.
• Isotype: IgG2a
• species: Mouse
• Clone: SNU3-36
• Purification: Purified IgG
• Conjugation: N/A
• Applications: Flow Cyt,IP,WB
• Dilution: Flow Cytometry:1/25 - 1/200
• Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
• Protein Concentration: 1 mg/ml
• Storage: Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
• Preservative: 0.09% Sodium Azide (NaN3)
• Shelf life: 18 months from date of despatch.
• Size: 0.1 mg

Gene Information

• Gene Name: Timd2 T cell immunoglobulin and mucin domain containing 2 [ Mus musculus ]
• Official Symbol: Timd2
• Synonyms: TIMD2; T cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; TIMD-2; T-cell membrane protein 2; T-cell immunoglobulin and mucin domain containing 2; G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662
• Gene ID: 171284
• mRNA Refseq: NM_001161355
• Protein Refseq: NP_001154827
• Function: receptor activity