T

  • Official Full Name

    T, brachyury homolog (mouse)

  • Overview

    The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

  • Synonyms

    T;T, brachyury homolog (mouse);TFT;SAVA;brachyury protein;protein T;T brachyury homolog

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Enterobacteria phage T4
  • Bacteriophage K3
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • Mouse
  • Rat
  • E.coli
  • In Vitro Cell Free System
  • Insect Cells
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
T-16350M Recombinant Mouse T Protein Mammalian Cells Mouse His
T-27668TH Recombinant Human T Wheat Germ Human Non 377 amino acids
T-27672TH Recombinant Human T Wheat Germ Human Non 99 amino acids
T-6500C Recombinant Chicken T Mammalian Cells Chicken His
T-1294HCL Recombinant Human T 293 Cell Lysate HEK293 Human Non
DMAB32033 Mouse Anti-TRIM27 Monoclonal Antibody Mouse Human Non
DMAB36386 Rat Anti-Timd2 Monoclonal Antibody Rat Mouse Non
DMAB36387 Rat Anti-Timd2 Monoclonal Antibody Rat Mouse Non
RFL22746EF Recombinant Full Length Enterobacteria Phage T4 Lysis Protein(T) Protein, His-Tagged E.coli Enterobacteria phage T4 His Full L. Full Length (1-218)
T-130H Recombinant Human T Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
T-510HF Recombinant Full Length Human T Protein In Vitro Cell Free System Human Full L. 377 amino acids
T-6267M Recombinant Mouse T Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
T-754B Recombinant Bacteriophage K3 T protein, His&Myc-tagged E.coli Bacteriophage K3 His&Myc 50-218a.a.
T-8938M Recombinant Mouse T Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
T-8938M-B Recombinant Mouse T Protein Pre-coupled Magnetic Beads HEK293 Mouse
TNFRSF25-10H Active Recombinant Human TNFRSF25 Protein, hIgG/His-tagged Insect Cells Human Fc&His 417

    Involved Pathway

    T involved in several pathways and played different roles in them. We selected most pathways T participated on our site, such as Cardiac Progenitor Differentiation,Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with T were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription TLE1,TLE2,IGF2BP1,ZCCHC12,TCF4,TLE4,HBP1,CYR61,BCL9,AES
    Cardiac Progenitor Differentiation LIN28A,TBX20,BMP1,TBX5,SOX1,NIPAL1,ROR2,SIRPA,ZFP42,IRX4

    Protein Function

    T has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by T itself. We selected most functions T had, and list some proteins which have the same functions with T. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor binding MIXL1,Ar,ATF4,TRP53,WWP2,GATA1A,TOX2,MTDH,CREBBP,ANKRD1
    RNA polymerase II activating transcription factor binding ISL1,TBX3,NEUROD1,JUN,PITX2,POU1F1,MAD2L2,DUSP26,CREB1,TBX20
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding CIR1,NR5A1,MITF,GATA6,MYF6,FOXF2A,MYOD1,OLIG2,NKX2-5,MEIS1
    transcriptional repressor activity, RNA polymerase II transcription factor binding BHLHE40,AHRRA,CREBBP,RIMKLB,ELP2,MINA,MLIP,EOMES,PITX2,AHRRB
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MEOX2,GMEB1,KCNA3,ZNF257,TFAP2E,ZNF718,ZNF562,GCM1,TCF3,PBX1
    transcription factor activity, sequence-specific DNA binding ZNF45,VDRB,TFAP2B,BACH1A,FOXG1,HOXA13,SOX13,PKNOX1,MTA1,TADA3
    RNA polymerase II distal enhancer sequence-specific DNA binding H3F3A,REL,MEOX2,NFE2L2,FLI1,CDX1,MIXL1,PROP1,ZBTB16,H2AFZ

    Interacting Protein

    T has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with T here. Most of them are supplied by our site. Hope this information will be useful for your research of T.

    Resources

    References

    • Yang, YR; Feng, JD; et al. Immune Responses to a Recombinant Rv0057-Rv1352 Fusion Protein of Mycobacterium tuberculosis. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:39-48(2015).
    • Law, JKY; Susloparova, A; et al. Human T cells monitored by impedance spectrometry using field-effect transistor arrays: A novel tool for single-cell adhesion and migration studies. BIOSENSORS & BIOELECTRONICS 67:170-176(2015).

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