Native Human PROS1 Protein

• Cat.No.: PROS1-31218TH
• Product Overview: Purified full length native human Protein S, isolated from fresh frozen plasma, is a single chain protein containing 10 gla residues in the NH2-terminal domain and 4 epidermal growth factor (EGF) domains, MW 69kDa.Post translational modifications: one bet

Specification

• Description: This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.
• Tissue specificity: Plasma.
• Form: Liquid
• Purity: Immunogen affinity purified
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 4 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 laminin G-like domains.
• Tag: Non
• Full Length: Full L.

Gene Information

• Gene Name: PROS1 protein S (alpha) [ Homo sapiens ]
• Official Symbol: PROS1
• Synonyms: PROS1; protein S (alpha); PROS; vitamin K-dependent protein S
• Gene ID: 5627
• mRNA Refseq: NM_000313
• Protein Refseq: NP_000304
• MIM: 176880
• Uniprot ID: P07225
• Chromosome Location: 3p11-q11.2
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: calcium ion binding; endopeptidase inhibitor activity