Native Human Neutrophil Elastase (ELA-2)

• Cat.No.: ELANE-8236H
• Product Overview: Human Neutrophil Elastase (ELA-2) was purified from Human Neutrophils.

Specification

• Description: Human Neutrophils, also known as neutrophilic polymorphonuclear leukocytes, are the major class of white blood cell in human peripheral blood. Human Neutrophil(s), have a multilobed nucleus and neutrophilic granules. Neutrophil(s) are phagocytes and have an important role in engulfing and killing extracellular pathogens.
• Source: Human Neutrophils
• Species: Human
• Form: Lyophilized from 50 mM acetate buffer
• Purity: >95% by SDS-PAGE
• Unit Definition: One unit will hydrolyze one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37 °C and pH 7.5.
• Stability: 2 years
• Tag: Non

Gene Information

• Gene Name: ELANE elastase, neutrophil expressed [ Homo sapiens ]
• Official Symbol: ELANE
• Synonyms: ELANE; elastase, neutrophil expressed; ELA2, elastase 2, neutrophil; neutrophil elastase; HLE; HNE; leukocyte elastase; medullasin; NE; elastase-2; PMN elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow se
• Gene ID: 1991
• mRNA Refseq: NM_001972
• Protein Refseq: NP_001963
• MIM: 130130
• UniProt ID: P08246
• Chromosome Location: 19p13.3
• Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem; Systemic lupus erythematosus, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem
• Function: bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protease binding; protein binding; serine-type endopeptidase activity