Elane
-
Official Full Name
elastase, neutrophil expressed -
Overview
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009] -
Synonyms
ELANE;elastase, neutrophil expressed;GE;NE;HLE;HNE;ELA2;SCN1;PMN-E;neutrophil elastase;elastase-2;medullasin;PMN elastase;leukocyte elastase;elastase 2, neutrophil;human leukocyte elastase;polymorphonuclear elastase;bone marrow serine protease;granulocyte-derived elastase
Recombinant Proteins
- Human
- Mouse
- Dog
- Human Neutrophils
- Mammalian Cells
- E.coli
- Human Blood
- Wheat Germ
- Human Cells
- HEK293
- Yeast
- Human Neutrophil
- Non
- His
- GST&His
- GST
- Avi&His
- Avi&Fc&His
- His&SUMO
- Avi&His&MBP
Involved Pathway
Elane involved in several pathways and played different roles in them. We selected most pathways Elane participated on our site, such as Activation of Matrix Metalloproteinases,C-MYB transcription factor network,Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Elane were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | MMP17,PCOLCE,MMP11,TRAPPC4,P3H2,MUSK,DMP1,SPARC,COL10A1,LOXL1 |
| Degradation of the extracellular matrix | TIMP2,COL25A1,MMP17,MGC174152,COL23A1,COL17A1,MMP24,ACAN,ADAM15,CTSS |
| amb2 Integrin signaling | MST1R,NIPAL1,LPA,CYR61,HP,MST1 |
| Systemic lupus erythematosus | GRIN2B,CD40LG,HLA-DPA1,H2AFB2,HLA-DMB,SNRPD1,GM14476,HIST1H2AJ,HIST1H2AO,H2AFX |
| Collagen degradation | COL23A1,MGC174857,CTSB,MGC174155,CTSLL,COL15A1B,CTSD,MMP12,MMP13,MGC174152 |
| Transcriptional misregulation in cancer | ERG,PLAU,IL6,FUT8,TP53,NUPR1,NFKB1,SPINT1,LRP2BP,ASPSCR1 |
| C-MYB transcription factor network | SLC25A3,ADA,CDKN1B,CDK6,MYB,CSF1R,CEBPA,YEATS4,CEBPB,PTCRA |
| Activation of Matrix Metalloproteinases | FURINB,MMP11,CTSK,MMP17,MMP15,CTSLL,TIMP2,MMP24,TIMP2B,MGC174857 |
Protein Function
Elane has several biochemical functions, for example, RNA polymerase II transcription corepressor activity,cytokine binding,endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Elane itself. We selected most functions Elane had, and list some proteins which have the same functions with Elane. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | KLK2,OVCH2,KLK1B3,ST14A,PARL,CELA2A,PRSS59.1,APEH,PRSS33,PCSK4 |
| protein binding | MED6,RAD23B,CD1A,CELF1,LZTS1,Ntng2,HHLA3,AQP5,EVC2,KIAA0368 |
| endopeptidase activity | PSMA2,KLK1B11,CPNE1,KLK1B1,PSMB11,MME,KLK1B8,PSMA3,MMP1A,NCSTN |
| heparin binding | CECR1,RPL22,PF4,LIPH,NRP2,SERPINA10,NRP1A,BSPH1,FGFR4,CCL23 |
| protease binding | C10orf2,SERPINA5,TIMP2A,NDUFS7,TYSND1,MBL1,VWF,INS,LDLR,SERPINB13 |
| cytokine binding | IFNGR1,TNFRSF11A,CNTFR,CRLF1,CSF1RA,CHRD,KITA,CD74,CSF1R,NOG |
| peptidase activity | C1rb,F9B,PLAUB,MBTPS2,MMP13A,PRSS48,MMP30,CAPN3,NOTS,DESI2 |
| RNA polymerase II transcription corepressor activity | URI1,BEND6,SIN3B,SIN3AA,TXLNB,TLE1,SIN3A,HDGF,TCERG1,CITED2 |
Interacting Protein
Elane has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Elane here. Most of them are supplied by our site. Hope this information will be useful for your research of Elane.
SERPINA1;SLPI;iovo_melga;Col17a1;GZMB;P/V/C
Resources
Research Area
Serine Proteases and RegulatorsInflammatory Mediators
Neutrophils
Asthma Therapeutic Targets
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References
