Native Human Insulin-Like Growth Factor 2 (somatomedin A)

• Cat.No.: IGF2-621H
• Product Overview: Native human IGF2 is expressed in E. coli, the final productcontains three major isoforms of IGF2 corresponding to MW 16.1, 17.0 and 17.6kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Human IGF2 is synthesized as a 156 amino acid precursor protein,known as proIGF2. This protein includes an 87 amino acid C-terminal regionknown as the E-domain. A proteolysis step releases the mature 67 amino acidIGF2 polypeptide. The proIGF2 proteins make up 10-20% of circulating IGF2.Pro-IGF2 proteins are secreted by some tumor cell lines and levels areelevated in non-islet cell tumor hypoglycemia.
• Form: Lyophilizedwhite powder. Dried from 0.1 M acetic acid and stored under dry nitrogen at aslight vacuum (-25 kPa).
• Purity: 88%
• Biological Activity: Stimulatesprotein synthesis in rat L6 myoblasts.
• Reconstitution: Dissolvein dilute acid (10 mM HCl or 0.1 M acetic acid), aliquot and store at -20°C. Avoidrepeated freeze-thaw cycles. For low concentrations (< 1 mg/ml) inclusionof a carrier protein such as BSA is recommended.
• Storage: Lyophilized protein is stable atleast 2 years at 2-4°C.
• OfficialSymbol: IGF2

Gene Information

• Gene Name: IGF2insulin-like growth factor 2 (somatomedin A) [ Homo sapiens ]
• Synonyms: IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II; somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013;OTTHUMP00000011015; OTTHUMP00000011016; OTTHUMP00000011017; OTTHUMP00000011018;OTTHUMP00000011157; OTTHUMP00000011158; OTTHUMP000000220667; insulin-likegrowth factor type 2; Insulin-like growth factor II Ala-25 Del; Preptin;PP1446; chromosome 11 open reading frame 43
• Gene ID: 3481
• mRNA Refseq: NM_000612
• Protein Refseq: NP_000603
• MIM: 147470
• UniProt ID: P01344
• Chromosome Location: 11p15.5
• Pathway: Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Singling Pathway; Regulationof Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth FactorBinding Proteins (IGFBPs)
• Function: growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity